Invention Grant
US09227982B2 4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors
有权
用作阻聚酶抑制剂的4-氧代-3,5,7,8-四氢-4H-吡喃并[4,3-d]嘧啶基化合物
![4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors](/docs/US/2016-01-05/US09227982B2/abs.jpg.600x600.jpg)
- Patent Title: 4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors
- Patent Title (中): 用作阻聚酶抑制剂的4-氧代-3,5,7,8-四氢-4H-吡喃并[4,3-d]嘧啶基化合物
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Application No.: US14154170Application Date: 2012-07-13
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Publication No.: US09227982B2Publication Date: 2016-01-05
- Inventor: Atwood Kim Cheung , Donovan Noel Chin , Jianmei Fan , Michael David Shultz , Ronald Charles Tomlinson
- Applicant: Atwood Kim Cheung , Donovan Noel Chin , Jianmei Fan , Michael David Shultz , Ronald Charles Tomlinson
- Applicant Address: CH Basel
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH Basel
- Agent Qian Zhang
- Priority: WOPCT/US2012/046699 20120713
- International Application: PCT/US2012/046699 WO 20120713
- International Announcement: WO2013/010092 WO 20130117
- Main IPC: A01N43/90
- IPC: A01N43/90 ; A61K31/519 ; C07D491/00 ; C07D495/00 ; C07D491/052
![4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors](/abs-image/US/2016/01/05/US09227982B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides for compounds of formula (I) wherein R1 and R2 are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.
Public/Granted literature
- US20150210709A1 4-OXO-3,5,7,8-TETRAHYDRO-4H-PYRANO[4,3-D]PYRMINIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS Public/Granted day:2015-07-30
Information query
IPC分类:
