A method of operating a vehicle drive-train comprising an internal combustion engine and a transmission system functionally connected to the internal combustion engine. The transmission has an interlocking shifting element, one shifting element half of which is functionally connected to the transmission input shaft while the other shifting element half is functionally connected to a transmission output shaft. Upon receipt of a command to change the transmission from a neutral position, in which a force flow through the transmission is interrupted, to an operating condition, in which the force flow through the transmission is produced, the interlocking shifting element is changed to an engaged operating condition. A speed difference between the shifting element halves is brought by varying the speed of the internal combustion engine into a speed difference window within which the interlocking shifting element can be changed to its engaged operating condition.