- 专利标题: Opioid agonist/antagonist combinations
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申请号: US14214659申请日: 2014-03-14
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公开(公告)号: US09205082B2公开(公告)日: 2015-12-08
- 发明人: Robert F. Kaiko , Robert D. Colucci
- 申请人: Purdue Pharma L.P.
- 申请人地址: US CT Stamford
- 专利权人: Purdue Pharma L.P.
- 当前专利权人: Purdue Pharma L.P.
- 当前专利权人地址: US CT Stamford
- 代理机构: Dechert LLP
- 主分类号: A61K9/14
- IPC分类号: A61K9/14 ; A61K31/485 ; A61K31/16 ; A61K31/60 ; A61K45/06 ; A61K31/137 ; A61K31/451 ; A61K9/16
摘要:
The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, “aversive” experience in physically dependent addicts (e.g., precipitated abstinence syndrome).
公开/授权文献
- US20140200236A1 OPIOID AGONIST/ANTAGONIST COMBINATIONS 公开/授权日:2014-07-17
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