Invention Grant
- Patent Title: Morpholinylbenzotriazines for use in cancer therapy
- Patent Title (中): 用于癌症治疗的吗啉基苯并三嗪
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Application No.: US14351773Application Date: 2012-10-30
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Publication No.: US09187469B2Publication Date: 2015-11-17
- Inventor: Werner Mederski , Thomas Fuchss , Ulrich Emde , Hans-Peter Buchstaller
- Applicant: Merck Patent GmbH
- Applicant Address: DE Darmstadt
- Assignee: Merck Patent GmbH
- Current Assignee: Merck Patent GmbH
- Current Assignee Address: DE Darmstadt
- Agency: EMD Serono Research and Development Institute
- Agent Dwight D. Kim
- Priority: DE102011118830 20111118
- International Application: PCT/EP2012/004542 WO 20121030
- International Announcement: WO2013/072015 WO 20130523
- Main IPC: C07D401/06
- IPC: C07D401/06 ; C07D401/14 ; C07D409/14 ; C07D417/14 ; C07D471/04 ; C07D487/04 ; C07D253/08 ; C07F7/18 ; A61K31/5377 ; A61K45/06 ; A61N5/10 ; C07F7/08 ; C07F7/10

Abstract:
The invention relates to compounds of the formula (I) in which R1, L and m have the meaning indicated in the claims, and/or physiologically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios.The compounds of the formula (I) can be used for the inhibition of serine/threonine protein kinases and for the sensitization of cancer cells to anticancer agents and/or ionizing radiation. The invention also relates to the use of the compounds of the formula (I) in the prophylaxis, therapy or progress control of cancer, tumors, metastases or angiogenesis disorders, in combination with radiotherapy and/or an anticancer agent. The invention furthermore relates to a process for the preparation of the compounds of the formula (I) by reaction of compounds of the formulae (II) and (III) and optionally conversion of a base or acid of the compounds of the formula (I) into a salt thereof.
Public/Granted literature
- US20140275072A1 MORPHOLINYLBENZOTRIAZINES FOR USE IN CANCER THERAPY Public/Granted day:2014-09-18
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