发明授权
US09164103B2 Monitoring and inhibiting human immunodeficiency virus infection by modulating HMGB1 dependent triggering of HIV-1 replication and persistence
有权
通过调节HMGB1依赖性触发HIV-1复制和持续性来监测和抑制人体免疫缺陷病毒感染
- 专利标题： Monitoring and inhibiting human immunodeficiency virus infection by modulating HMGB1 dependent triggering of HIV-1 replication and persistence
- 专利标题（中）： 通过调节HMGB1依赖性触发HIV-1复制和持续性来监测和抑制人体免疫缺陷病毒感染
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申请号： US14073112申请日： 2013-11-06
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公开(公告)号： US09164103B2公开(公告)日： 2015-10-20
- 发明人: Marie-Lise Gougeon , Hela Saidi , Marie-Therese Melki , Beatrice Poirier-Beaudoin , Valerie Seffer
- 申请人： INSTITUT PASTEUR
- 申请人地址： FR Paris
- 专利权人： INSTITUT PASTEUR
- 当前专利权人： INSTITUT PASTEUR
- 当前专利权人地址： FR Paris
- 代理机构： Law Office of Salvatore Arrigo and Scott Lee, LLP
- 主分类号： G01N33/569
- IPC分类号： G01N33/569 ; G01N33/68 ; A61K31/00 ; A61K31/704
摘要：
Compositions and methods for modulating human immunodeficiency virus (HIV) infection involving substances that inhibit the ability of high mobility box 1 (HMGB1) protein to interact with natural killer (NK) cells. Therapeutic compositions comprising antibodies and drugs, such as glycyrrhizin, which bind to HMGB1. Methods of detecting or monitoring HIV infection involving detection or quantitation of HMGB1 or antibodies specific for HMGB1 in a biological sample.
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