Invention Grant
US09156845B2 4-(substituted amino)-7H-pyrrolo[2,3-d] pyrimidines as LRRK2 inhibitors
有权
4-（取代氨基）-7H-吡咯并[2,3-d]嘧啶作为LRRK2抑制剂
![4-(substituted amino)-7H-pyrrolo[2,3-d] pyrimidines as LRRK2 inhibitors](/docs/US/2015-10-13/US09156845B2/abs.jpg.600x600.jpg)
- Patent Title: 4-(substituted amino)-7H-pyrrolo[2,3-d] pyrimidines as LRRK2 inhibitors
- Patent Title (中): 4-（取代氨基）-7H-吡咯并[2,3-d]嘧啶作为LRRK2抑制剂
-
Application No.: US13928696Application Date: 2013-06-27
-
Publication No.: US09156845B2Publication Date: 2015-10-13
- Inventor: Paul Galatsis , Matthew Merrill Hayward , Bethany Lyn Kormos , Travis T. Wager , Lei Zhang , Antonia Friederike Stepan , Jaclyn Louise Henderson , Ravi G. Kurumbail , Patrick Robert Verhoest
- Applicant: Pfizer Inc.
- Applicant Address: US NY New York
- Assignee: Pfizer Inc.
- Current Assignee: Pfizer Inc.
- Current Assignee Address: US NY New York
- Agent John A. Wichtowski
- Main IPC: A61K31/519
- IPC: A61K31/519 ; C07D207/18 ; C07D487/04 ; C07D519/00
![4-(substituted amino)-7H-pyrrolo[2,3-d] pyrimidines as LRRK2 inhibitors](/abs-image/US/2015/10/13/US09156845B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides novel 4,5-disubstituted-7H-pyrrolo[2,3-d]pyrimidine derivatives of Formula I, and the pharmaceutically acceptable salts thereof wherein R1, R2, R3, R4 and R5 are as defined in the specification. The invention is also directed to pharmaceutical compositions comprising the compounds of formula I and to use of the compounds in the treatment of diseases associated with LRRK2, such as neurodegenerative diseases including Parkinson's disease or Alzheimer's disease, cancer, Crohn's disease or leprosy.
Public/Granted literature
- US20140005183A1 Novel 4-(Substituted Amino)-7H-Pyrrolo[2,3-d] Pyrimidines As LRRK2 Inhibitors Public/Granted day:2014-01-02
Information query
IPC分类:
