发明授权
- 专利标题： Pyridazine derivatives, compositions and methods for treating cognitive impairment
- 专利标题（中）： 哒嗪衍生物，治疗认知障碍的组合物和方法
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申请号： US13885569申请日： 2011-11-15
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公开(公告)号： US09145372B2公开(公告)日： 2015-09-29
- 发明人: John A. Lowe, III
- 申请人： John A. Lowe, III
- 申请人地址： US MD Baltimore
- 专利权人： AGENEBIO, INC.
- 当前专利权人： AGENEBIO, INC.
- 当前专利权人地址： US MD Baltimore
- 代理机构： Ropes & Gray LLP
- 代理商 Karen Mangasarian; Yang Xu
- 国际申请： PCT/US2011/060854 WO 20111115
- 国际公布： WO2012/068161 WO 20120524
- 主分类号： C07D403/00
- IPC分类号： C07D403/00 ; C07D405/00 ; C07D409/00 ; C07D401/00 ; C07D251/00 ; A61K31/50 ; C07D237/24 ; C07D413/04 ; C07D401/04 ; C07D403/04 ; C07D413/14
摘要：
This invention relates to pyridazine derivatives, compositions comprising therapeutically effective amounts of those pyridazine derivatives and methods of using those derivatives or compositions in treating central nervous system (CNS) disorders with cognitive impairment that are responsive to agonists of α5 subunit containing GABAA receptor, e.g., age-related cognitive impairment, Mild Cognitive Impairment (MCI), dementia, Alzheimer's Disease (AD), prodromal AD, post traumatic stress disorder (PTSD), schizophrenia and cancer-therapy-related cognitive impairment.
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