Invention Grant
- Patent Title: Peptides and related molecules that bind to TALL-1
- Patent Title (中): 结合TALL-1的肽和相关分子
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Application No.: US13938141Application Date: 2013-07-09
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Publication No.: US09139645B2Publication Date: 2015-09-22
- Inventor: Hosung Min , Hailing Hsu , Fei Xiong
- Applicant: AMGEN INC.
- Applicant Address: US CA Tousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Tousand Oaks
- Agency: Perkins Coie LLP
- Agent Patrick D. Morris
- Main IPC: C07K7/08
- IPC: C07K7/08 ; C07K14/00 ; C07K16/24 ; C07K1/04 ; C07K14/47 ; C07K14/715 ; C12N15/10 ; C40B40/02 ; A61K38/00
Abstract:
The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz2Lz4 wherein z2 is an amino acid residue and z4 is threonyl or isoleucyl. Exemplary molecules comprise a sequence of the formulae (SEQ. ID. NO: 100) a1a2a3CDa6La8a9a10Ca12a13a14, (SEQ. ID. NO: 104) b1b2b3Cb5b6Db8Lb10b11b12b13b14Cb16b17b18 (SEQ. ID. NO: 105) c1c2c3Cc5Dc7Lc9c10c11c12c13c14Cc16c17c18 (SEQ. ID. NO: 106) d1d2d3Cd5d6d7WDd10Ld13d14d15Ld16d17d18 (SEQ. ID. NO: 107) e1e2e3Ce5e6e7De9Le11Ke13Ce15e16e17e18 (SEQ. ID NO: 109) f1f2f3Kf5Df7Lf9f10Qf12f13f14 wherein the substituents are as defined in the specification. The invention further comprises compositions of matter of the formula (X1)a—V1—(X2)b wherein V1 is a vehicle that is covalently attached to one or more of the above TALL-1 modulating compositions of matter. The vehicle and the TALL-1 modulating composition of matter may be linked through the N- or C-terminus of the TALL-1 modulating portion. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain.
Public/Granted literature
- US20140234334A1 PEPTIDES AND RELATED MOLECULES THAT BIND TO TALL-1 Public/Granted day:2014-08-21
Information query
