Various techniques are disclosed for facilitating manipulation of virtualized storage volumes and/or file systems of one or more different types of operating systems (OSs) implemented on distributed computer systems. According to different embodiments, various aspects may be directed to different embodiments of virtualized filer appliances and/or filer applications which may be used for facilitating manipulation of virtualized storage volumes and/or file systems of one or more different types of operating systems (OSs) implemented on distributed computer systems. In at least one embodiment, a filer appliance may be implemented as a virtual appliance that includes functionality for performing automated file-level and/or volume-level operations for a selected set of file systems. In one embodiment, a filer appliance may be implemented as a virtual machine which is configured or designed to handle managing of one or more volumes. In one embodiment, the filer appliance may include one or more virtual interfaces for interfacing with one or more virtual volumes and/or one or more other virtual appliances, virtual applications, etc. Various other techniques are disclosed herein for facilitating dynamic and automated configuration of virtual appliances implemented at distributed computing systems.