A photoacoustic detector wherein a detector response transfer function can be measured at various times under predetermined conditions during the life of the detector. One or more of the time related transfer functions each can, when acquired, be compared to the stored initial transfer function established at initial manufacture and calibration of the detector. Span and baseline correction values can be determined. These values can be used to compensate detected output values during normal operation. Time related transfer functions can be compared to each other as well as to the stored initial transfer function.