发明授权
- 专利标题： Molecules of the card-related protein family and uses thereof
- 专利标题（中）： 卡相关蛋白家族的分子及其用途
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申请号： US13452089申请日： 2012-04-20
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公开(公告)号： US09085639B2公开(公告)日： 2015-07-21
- 发明人: John Bertin
- 申请人： John Bertin
- 申请人地址： US MA Cambridge
- 专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Millennium Pharmaceuticals, Inc.
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; A61K38/00
摘要：
Novel CARD-9, CARD-10, or CARD-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-9, CARD-10, or CARD-11 proteins, the invention further provides CARD-9, CARD-10, or CARD-11, fusion proteins, antigenic peptides and anti-CARD-9, CARD-10, or CARD-11 antibodies. The invention also provides CARD-9, CARD-10, or CARD-11 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-9, CARD-10, or CARD-11 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
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