Embodiments of the present invention disclose a remote control method, a remote controller, a remote control response method, and a set-top box. The remote control method includes: sensing a user selection operation event, and judging a type of the user selection operation event; when the type of the user selection operation event is corresponding to an operation control mode type, sending a user selection operation event message; when the type of the user selection operation event is not corresponding to the operation control mode type, switching an operation control mode. The remote control method complies with a use habit of a user in terms of operation control mode switching, so that the user may trigger operation control mode switching through natural association without special learning, thereby improving a user experience effect.