发明授权
US09061029B2 Method of treating proliferative disorders and other pathological conditions mediated by Bcr-Abl, c-Kit, DDR1, DDR2 or PDGF-R kinase activity 有权
治疗由Bcr-Abl,c-Kit,DDR1,DDR2或PDGF-R激酶活性介导的增殖性疾病和其他病理状态的方法

  • 专利标题: Method of treating proliferative disorders and other pathological conditions mediated by Bcr-Abl, c-Kit, DDR1, DDR2 or PDGF-R kinase activity
  • 专利标题(中): 治疗由Bcr-Abl,c-Kit,DDR1,DDR2或PDGF-R激酶活性介导的增殖性疾病和其他病理状态的方法
  • 申请号: US13509626
    申请日: 2010-11-17
  • 公开(公告)号: US09061029B2
    公开(公告)日: 2015-06-23
  • 发明人: Neil GallagherOphelia Yin
  • 申请人: Neil GallagherOphelia Yin
  • 申请人地址: CH Basel
  • 专利权人: Novartis AG
  • 当前专利权人: Novartis AG
  • 当前专利权人地址: CH Basel
  • 代理商 Gregory Houghton
  • 国际申请: PCT/US2010/056926 WO 20101117
  • 国际公布: WO2011/062927 WO 20110526
  • 主分类号: A61K31/506
  • IPC分类号: A61K31/506 C07D239/69 A61K9/00
Method of treating proliferative disorders and other pathological conditions mediated by Bcr-Abl, c-Kit, DDR1, DDR2 or PDGF-R kinase activity
摘要:
The present invention relates to a regimen for the administration of a pyrimidylaminobenzamide of formula I wherein the radicals as defined herein, or of a pharmaceutically acceptable salt thereof, for the treatment of proliferative disorders, particularly solid and liquid tumors, and other pathological conditions mediated by the Bcr-Abl oncoprotein, the cell transmembrane tyrosine kinase receptor c-Kit, DDR1 (discoidin domain receptor 1), DDR2 (discoidin domain receptor 2) or PDGF-R (platelet derived growth factor receptor) kinase activity, wherein the pyrimidylaminobenzamide of formula I and, optionally, pharmaceutically acceptable carriers, are dispersed in a fruit preparation.
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