发明授权
US09061029B2 Method of treating proliferative disorders and other pathological conditions mediated by Bcr-Abl, c-Kit, DDR1, DDR2 or PDGF-R kinase activity
有权
治疗由Bcr-Abl,c-Kit,DDR1,DDR2或PDGF-R激酶活性介导的增殖性疾病和其他病理状态的方法
- 专利标题: Method of treating proliferative disorders and other pathological conditions mediated by Bcr-Abl, c-Kit, DDR1, DDR2 or PDGF-R kinase activity
- 专利标题(中): 治疗由Bcr-Abl,c-Kit,DDR1,DDR2或PDGF-R激酶活性介导的增殖性疾病和其他病理状态的方法
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申请号: US13509626申请日: 2010-11-17
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公开(公告)号: US09061029B2公开(公告)日: 2015-06-23
- 发明人: Neil Gallagher , Ophelia Yin
- 申请人: Neil Gallagher , Ophelia Yin
- 申请人地址: CH Basel
- 专利权人: Novartis AG
- 当前专利权人: Novartis AG
- 当前专利权人地址: CH Basel
- 代理商 Gregory Houghton
- 国际申请: PCT/US2010/056926 WO 20101117
- 国际公布: WO2011/062927 WO 20110526
- 主分类号: A61K31/506
- IPC分类号: A61K31/506 ; C07D239/69 ; A61K9/00
摘要:
The present invention relates to a regimen for the administration of a pyrimidylaminobenzamide of formula I wherein the radicals as defined herein, or of a pharmaceutically acceptable salt thereof, for the treatment of proliferative disorders, particularly solid and liquid tumors, and other pathological conditions mediated by the Bcr-Abl oncoprotein, the cell transmembrane tyrosine kinase receptor c-Kit, DDR1 (discoidin domain receptor 1), DDR2 (discoidin domain receptor 2) or PDGF-R (platelet derived growth factor receptor) kinase activity, wherein the pyrimidylaminobenzamide of formula I and, optionally, pharmaceutically acceptable carriers, are dispersed in a fruit preparation.
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