The present disclosure provides methods and devices for locating a plurality of interested objects in CT imaging. Location of the interested objects in the three-dimensional space can be determined by using three projection images that are substantially perpendicular to each other. The method can rapidly locate interested objects in a CT image without pre-reconstruction of the CT image even if there are a plurality of interested objects in the field of view. The algorithm does not involve interactive steps. The method is rapid and effective, and thus applicable to industrial applications.