发明授权
- 专利标题： Selective caspase inhibitors and uses thereof
- 专利标题（中）： 选择性胱天蛋白酶抑制剂及其用途
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申请号： US13321681申请日： 2010-05-21
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公开(公告)号： US09045524B2公开(公告)日： 2015-06-02
- 发明人: Jan-Eric Ahlfors , Khalid Mekouar
- 申请人： Jan-Eric Ahlfors , Khalid Mekouar
- 申请人地址： CH
- 专利权人： NOVAGENESIS FOUNDATION
- 当前专利权人： NOVAGENESIS FOUNDATION
- 当前专利权人地址： CH
- 代理机构： Knobbe, Martens, Olson & Bear LLP
- 优先权： WOPCT/CA2009/000696 20090521
- 国际申请： PCT/CA2010/000783 WO 20100521
- 国际公布： WO2010/133000 WO 20101125
- 主分类号： C07K5/08
- IPC分类号： C07K5/08 ; C07K5/10 ; A61K38/00 ; C07K5/02 ; C07K5/093 ; C07K14/81
摘要：
The present invention relates to compounds of Formula I, II, IVC, VIIIC, IXC, or XC and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds for the selective inhibition of one or more caspases. Also described are methods where the compounds of Formula I, II, IVC, VIIIC, IXC, or XC are used in the prevention and/or treatment of various diseases and conditions in subjects, including caspase-mediated diseases such as sepsis, myocardial infarction, ischemic stroke, spinal cord injury (SCI), traumatic brain injury (TBI) and neurodegenerative disease (e.g. multiple sclerosis (MS) and Alzheimer's, Parkinson's, and Huntington's diseases). Processes for synthesizing tripeptides are provided.
公开/授权文献
- US20120157394A1 SELECTIVE CASPASE INHIBITORS AND USES THEREOF 公开/授权日：2012-06-21
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