A pattern password trajectory configuration system used in an electronic device with a graphics input interface and a method using the same are provided. The disclosed pattern password trajectory configuration system includes a central processing module, a pattern defining module electronically connected the central processing module for defining the graphics input interface into a central block and multiple blocks neighboring the central block and assigning different data codes to the different blocks neighboring the central block, a sliding direction defining module electronically connected to the central processing module for assigning different prime numbers to define different sliding directions moving along the blocks neighboring the central block, and a touch sequence defining module electronically connected to the central processing module for counting and recording touch sequences of sliding among the blocks neighboring the central block.