发明授权
US09029520B2 B7-1-PE40KDEL exotoxin fusion gene-based DNA vaccine and the use thereof
有权
B7-1-PE40KDEL外毒素融合基因DNA疫苗及其用途
- 专利标题： B7-1-PE40KDEL exotoxin fusion gene-based DNA vaccine and the use thereof
- 专利标题（中）： B7-1-PE40KDEL外毒素融合基因DNA疫苗及其用途
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申请号： US13993685申请日： 2011-09-20
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公开(公告)号： US09029520B2公开(公告)日： 2015-05-12
- 发明人: Yongzhi Xi , Yuan Luo
- 申请人： Yongzhi Xi , Yuan Luo
- 申请人地址： CN Beijing
- 专利权人： Affiliated Hospital of Academy of Military Medical Sciences, PLA
- 当前专利权人： Affiliated Hospital of Academy of Military Medical Sciences, PLA
- 当前专利权人地址： CN Beijing
- 代理机构： Oblon, McClelland, Maier & Neustadt, L.L.P.
- 优先权： CN201110023985 20110114
- 国际申请： PCT/CN2011/079862 WO 20110920
- 国际公布： WO2012/094905 WO 20120719
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C12N15/00 ; C07K1/00 ; A61K48/00 ; C07K14/00 ; C07K14/21 ; C07K14/705 ; A61K39/00
摘要：
The present invention relates to the fields of immunology and molecular biology and related to a B7-1-PE40KDEL exotoxin fusion gene-based DNA vaccine and the use thereof. Specifically, the DNA vaccine contains a recombinant expression vector, and the vector contains exotoxin fusion gene B7-1-PE40KDEL, which is effectively ligated into selected eukaryotic expression vectors, such as pcDNA3.1/Zeo(+), pWLNEO, pSV2CAT, pOG44, pXT1, pSG, pSVK3, pBPV, pMSG, pSVL, and adenovirus. The invention also relates to the exotoxin fusion gene B7-1-PE40KDEL, the encoded exotoxin fusion protein, a recombinant expression vector that contains the exotoxin fusion gene, and compositions that contain the recombinant expression vector. The DNA vaccine in this invention has a good effect on the treatment or prevention of allogeneic tissue/organ transplant rejection and hematopoietic stem cell transplantation rejection such as GVHD.
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