Invention Grant
US08999918B2 Bis(fluoroalkyl)-1,4-benzodiazepinone compounds and prodrugs thereof
有权
双（氟烷基）-1,4-苯并二氮杂酮化合物及其前药
- Patent Title: Bis(fluoroalkyl)-1,4-benzodiazepinone compounds and prodrugs thereof
- Patent Title (中): 双（氟烷基）-1,4-苯并二氮杂酮化合物及其前药
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Application No.: US14032333Application Date: 2013-09-20
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Publication No.: US08999918B2Publication Date: 2015-04-07
- Inventor: Ashvinikumar V. Gavai , George V. DeLucca , Daniel O'Malley , Patrice Gill , Claude A. Quesnelle , Brian E. Fink , Yufen Zhao , Francis Y. Lee
- Applicant: Bristol-Myers Squibb Company
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary D. Greenblatt
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K47/00 ; C07D243/24 ; A61K31/5513 ; A61K31/573 ; A61K31/675 ; A61K38/05 ; A61K45/06 ; C07D401/04 ; C07F9/645 ; C07K5/062 ; C07D243/18 ; C07D243/26 ; C07F9/12 ; A61K9/00 ; A61K9/08 ; A61K31/138 ; A61K31/337 ; A61K31/506 ; A61K31/555 ; A61K9/48 ; A61K47/48
Abstract:
Disclosed are compounds of Formula (I) and/or salts thereof: wherein R1 is —CH2CH2CF3; R2 is —CH2CH2CF3 or —CH2CH2CH2CF3; R3 is H, —CH3, or Rx; R4 is H or Ry; Ring A is phenyl or pyridinyl; and Rx, Ry, Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer; or as prodrugs of such compounds.
Public/Granted literature
- US20140087992A1 BIS(FLUOROALKYL)-1,4-BENZODIAZEPINONE COMPOUNDS AND PRODRUGS THEREOF Public/Granted day:2014-03-27
Information query
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