Invention Grant
- Patent Title: Human tissue factor antibody and uses thereof
- Patent Title (中): 人组织因子抗体及其用途
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Application No.: US14230128Application Date: 2014-03-31
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Publication No.: US08999333B2Publication Date: 2015-04-07
- Inventor: Juan Carlos Almagro , Glenn Mark Anderson , Ellen Chi , Christian Martinez , Gopalan Raghunathan , Ronald Swanson , Alexey Teplyakov , Kam-Fai Tse , Sheng-Jiun Wu , Hong Mimi Zhou
- Applicant: Janssen Biotech, Inc.
- Applicant Address: US PA Horsham
- Assignee: Janssen Biotech, Inc.
- Current Assignee: Janssen Biotech, Inc.
- Current Assignee Address: US PA Horsham
- Agent Sean C. Brock
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/40 ; C07K16/36 ; C07K16/46 ; A61K39/00 ; C07K16/28
Abstract:
The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.
Public/Granted literature
- US20140234304A1 HUMAN TISSUE FACTOR ANTIBODY AND USES THEREOF Public/Granted day:2014-08-21
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