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发明授权
US08980877B2 Spirocyclic derivatives as histone deacetylase inhibitors 有权
螺环衍生物作为组蛋白脱乙酰酶抑制剂

Spirocyclic derivatives as histone deacetylase inhibitors
摘要：
This invention is related to new histone deacetylase inhibitors according to the general formula (I), wherein: m and n are independently zero or an integer from 1 to 4; p is zero or an integer from 1 to 3, with the proviso that when p is zero, n and m cannot be both 1; R is hydrogen; C1-C6 alkyl, optionally substituted by C3-C8 cycloalkyl, C6-C10 aryl or hetero(C2-C9)aryl; (CO)R2; (SO2)R3; C3-C8 cycloalkyl; C6-C10 aryl; or hetero(C2-C9)aryl; R1 is halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy; Y is CH2 or NR4; Z is C═R5; and R2, R3, R4, and R5 are as further defined in the specification; and pharmaceutical acceptable salts thereof.
摘要（中）：

本发明涉及根据通式（I）的新的组蛋白脱乙酰酶抑制剂，其中：m和n独立地为0或1至4的整数; p为0或1至3的整数，条件是当p为零时，n和m不能同时为1; R是氢; 任选被C 3 -C 8环烷基，C 6 -C 10芳基或杂（C 2 -C 9）芳基取代的C 1 -C 6烷基; （CO）R2; （SO2）R3; C3-C8环烷基; C6-C10芳基; 或杂（C 2 -C 9）芳基; R1是卤素，C1-C6烷基，C1-C6卤代烷基，C1-C6烷氧基，C1-C6卤代烷氧基; Y是CH 2或NR 4; Z为C = R5; R2，R3，R4和R5如说明书中进一步定义; 及其药学上可接受的盐。

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