Invention Grant
US08980257B2 Antibody being capable of binding to transforming growth factor alpha and having growth-suppressing activity on cancers having Ras gene mutation
有权
抗体能够结合转化生长因子α并具有对具有Ras基因突变的癌症的生长抑制活性
- Patent Title: Antibody being capable of binding to transforming growth factor alpha and having growth-suppressing activity on cancers having Ras gene mutation
- Patent Title (中): 抗体能够结合转化生长因子α并具有对具有Ras基因突变的癌症的生长抑制活性
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Application No.: US13698420Application Date: 2011-05-17
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Publication No.: US08980257B2Publication Date: 2015-03-17
- Inventor: Makoto Kaneda , Yoshihiro Fujii , Yoshihiro Hayata , Yoshiro Kishi , Ichiro Yahara
- Applicant: Makoto Kaneda , Yoshihiro Fujii , Yoshihiro Hayata , Yoshiro Kishi , Ichiro Yahara
- Applicant Address: JP Aichi
- Assignee: Medical & Biological Laboratories Co., Ltd.
- Current Assignee: Medical & Biological Laboratories Co., Ltd.
- Current Assignee Address: JP Aichi
- Agency: Sughrue Mion, PLLC
- Priority: JP2010-114460 20100518
- International Application: PCT/JP2011/061347 WO 20110517
- International Announcement: WO2011/145629 WO 20111124
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/395 ; C07K16/00 ; C07K16/18 ; C07K16/24 ; C12N15/00 ; C12N15/09 ; C12N15/11 ; C12N15/13 ; C12N15/63 ; C12N5/10 ; C12N5/16 ; C12N5/18 ; C12N5/20 ; C12N5/22 ; C12N5/24 ; C12N5/26 ; C12N5/28 ; C07K16/22 ; C07K14/495
Abstract:
It has been found out that among antibodies showing reactivity with wild type TGF-α, antibodies less reactive with G79A-substituted TGF-α have an excellent growth-suppressing effect on cancer cells having a mutated Ras gene. Further, it has been found out that most of these antibodies have an activity of inhibiting EGFR tyrosine phosphorylation and/or an induction-suppressing activity on vascular endothelial cells.
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