Invention Grant
US08957068B2 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
有权
3-嘧啶-4-基 - 恶唑烷-2-酮作为突变体IDH的抑制剂
- Patent Title: 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
- Patent Title (中): 3-嘧啶-4-基 - 恶唑烷-2-酮作为突变体IDH的抑制剂
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Application No.: US14347481Application Date: 2012-09-26
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Publication No.: US08957068B2Publication Date: 2015-02-17
- Inventor: Thomas Raymond Caferro , Young Shin Cho , Abran Q. Costales , Huangshu Lei , Francois Lenoir , Julian Roy Levell , Gang Liu , Mark G. Palermo , Keith Bruce Pfister , Martin Sendzik , Cynthia Shafer , Michael David Shultz , Troy Smith , James Clifford Sutton , Bakary-Barry Toure , Fan Yang , Qian Zhao
- Applicant: Thomas Raymond Caferro , Young Shin Cho , Abran Q. Costales , Huangshu Lei , Francois Lenoir , Julian Roy Levell , Gang Liu , Mark G. Palermo , Keith Bruce Pfister , Martin Sendzik , Cynthia Shafer , Michael David Shultz , Troy Smith , James Clifford Sutton , Bakary-Barry Toure , Fan Yang , Qian Zhao
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Stephen Johnson
- International Application: PCT/IB2012/055133 WO 20120926
- International Announcement: WO2013/046136 WO 20130404
- Main IPC: C07D413/04
- IPC: C07D413/04 ; C07D413/14 ; A61K31/506 ; C07D487/04 ; C07D471/04 ; C07D487/08 ; C07D417/14 ; C07D498/10
Abstract:
The invention is directed to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
Public/Granted literature
- US20140235620A1 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH Public/Granted day:2014-08-21
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