Invention Grant
US08906921B2 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists
有权
4-烷氧基哒嗪衍生物作为快速解离的多巴胺2受体拮抗剂
- Patent Title: 4-alkoxypyridazine derivatives as fast dissociating dopamine 2 receptor antagonists
- Patent Title (中): 4-烷氧基哒嗪衍生物作为快速解离的多巴胺2受体拮抗剂
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Application No.: US12597166Application Date: 2008-04-18
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Publication No.: US08906921B2Publication Date: 2014-12-09
- Inventor: Gregor James MacDonald , José Manuel Bartolomé-Nebreda
- Applicant: Gregor James MacDonald , José Manuel Bartolomé-Nebreda
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Agent Hal B. Woodrow
- Priority: EP07106704 20070423
- International Application: PCT/EP2008/054731 WO 20080418
- International Announcement: WO2008/128995 WO 20081030
- Main IPC: A61K31/50
- IPC: A61K31/50 ; C07D237/02
Abstract:
The present invention relates to (1-benzyl-piperidin-4-yl)-(4-alkoxy-pyridazin-3-y1)-amines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
Public/Granted literature
- US20100063058A1 4-ALKOXYPYRIDAZINE DERIVATIVES AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS Public/Granted day:2010-03-11
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