发明授权
- 专利标题: BODIPY structure fluorescence dye for neural stem cell probe
- 专利标题(中): BODIPY结构荧光染料用于神经干细胞探针
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申请号: US13988734申请日: 2011-11-22
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公开(公告)号: US08889883B2公开(公告)日: 2014-11-18
- 发明人: Young-Tae Chang , Seong-Wook Yun , Duanting Zhai , Kit Mun Cheryl Leong
- 申请人: Young-Tae Chang , Seong-Wook Yun , Duanting Zhai , Kit Mun Cheryl Leong
- 申请人地址: SG Singapore SG Singapore
- 专利权人: National University of Singapore,Agency for Science, Technology and Research
- 当前专利权人: National University of Singapore,Agency for Science, Technology and Research
- 当前专利权人地址: SG Singapore SG Singapore
- 代理机构: Hamilton, Brook, Smith & Reynolds, P.C.
- 国际申请: PCT/SG2011/000411 WO 20111122
- 国际公布: WO2012/071012 WO 20120531
- 主分类号: C07F5/02
- IPC分类号: C07F5/02 ; C09B57/00 ; G01N33/58
摘要:
The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: I or a pharmaceutically acceptable salt thereof. The variables for structural Formula (I) are defined herein. Also described are methods for detection of neural stem cells, comprising using a compound of structural Formula (I) or pharmaceutically acceptable salts thereof. Compounds of structural Formula (I) can detect and separate neural stem cells without immunostaining, providing a much shorter and more convenient method for detection of neural stem cells.
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