The object of the present invention is to provide a golf ball that satisfies both of the flight distance at the shot with a driver, a long iron, and a middle iron and the controllability at the approach shot with a short iron and is also excellent in the abrasion resistance of the cover. The present invention provides a golf ball comprising a core consisting of a center and at least one intermediate layer covering the center, and a cover covering the core, wherein the cover is formed from a cover composition containing, as a resin component, a thermoplastic polyurethane (A) and a polyisocyanate mixture (B) in which a urethane prepolymer (b-1) having at least two isocyanate groups or a polyisocyanate (b-2) having at least three isocyanate groups is dispersed in a thermoplastic resin (b-3) which does not substantially react with an isocyanate group; and wherein the cover composition has a slab hardness of 60 or less in Shore D hardness, and the core has a hardness difference (Hs−Ho) between a surface hardness Hs and a center hardness Ho of from 15 to 50 in Shore D hardness.