A thermal regulation blanket includes a plurality of cells with a first reagent. A plurality of pouches with a second reagent are disposed within the plurality of cells. A plurality of dividers are disposed between each of the plurality of cells. A thermally conductive layer is disposed over the cells and the plurality of dividers. When the first reagent and the second reagent mix, a thermal reaction occurs which modifies a temperature of the thermally conductive layer. A method of providing thermal therapy to a patient includes positioning the patient on a thermal regulation blanket, an abdomen of the patient is engaged with at least one abdominal blanket of the thermal regulation blanket. At least one cell of the thermal regulation blanket is activated to begin providing thermal therapy to the patient. A temperature of the thermal regulation blanket is monitored with a temperature sensor. At least one additional cell is activated to adjust the temperature of the thermal regulation blanket.