发明授权
US08853237B2 Naphthyridinone analogs as mGluR5 positive allosteric modulators
有权
萘吡酮类似物作为mGluR5阳性变构调节剂
- 专利标题： Naphthyridinone analogs as mGluR5 positive allosteric modulators
- 专利标题（中）： 萘吡酮类似物作为mGluR5阳性变构调节剂
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申请号： US13340641申请日： 2011-12-29
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公开(公告)号： US08853237B2公开(公告)日： 2014-10-07
- 发明人: P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , Jason Manka , Jon Jacobs , Ya Zhou , José Manuel Bartolomé-Nebreda , Gregor James MacDonald , Susana Conde-Ceide , Carrie K. Jones
- 申请人： P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , Jason Manka , Jon Jacobs , Ya Zhou , José Manuel Bartolomé-Nebreda , Gregor James MacDonald , Susana Conde-Ceide , Carrie K. Jones
- 申请人地址： US TN Nashville
- 专利权人： Vanderbilt University
- 当前专利权人： Vanderbilt University
- 当前专利权人地址： US TN Nashville
- 代理机构： Ballard Spahr LLP
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; C07D513/02 ; C07D515/02
摘要：
In one aspect, the invention relates to naphthyridinone analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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