发明授权
US08853198B2 Agents for treating disorders involving modulation of ryanodine receptors
有权
用于治疗涉及调节兰诺定受体的疾病的药剂
- 专利标题： Agents for treating disorders involving modulation of ryanodine receptors
- 专利标题（中）： 用于治疗涉及调节兰诺定受体的疾病的药剂
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申请号： US14076474申请日： 2013-11-11
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公开(公告)号： US08853198B2公开(公告)日： 2014-10-07
- 发明人: Jiaming Yan , Sandro Belvedere , Yael Webb , Marc Bertrand , Nicole Villeneuve
- 申请人： Les Laboratoires Servier , Armgo Pharma, Inc.
- 申请人地址： FR Suresnes Cedex US NY Tarrytown
- 专利权人： Les Laboratoires Servier,ARMGO Pharma, Inc.
- 当前专利权人： Les Laboratoires Servier,ARMGO Pharma, Inc.
- 当前专利权人地址： FR Suresnes Cedex US NY Tarrytown
- 代理机构： Hueschen and Sage
- 优先权： EP12167732 20120511
- 主分类号： A61K31/554
- IPC分类号： A61K31/554 ; C07D281/10 ; A61K31/7088 ; C07D285/36
摘要：
The present invention relates to 1,4-benzothiazepine derivatives and their use to treat conditions, disorders and diseases associated with ryanodine receptors (RyRs) that regulate calcium channel functioning in cells. The invention also discloses pharmaceutical compositions comprising the compounds and uses thereof to treat diseases and conditions associated with RyRs, in particular cardiac, musculoskeletal and central nervous system (CNS) disorders.
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