发明授权
- 专利标题： GLP-1, exendin-4, peptide analogs and uses thereof
- 专利标题（中）： GLP-1，毒蜥外泌肽-4，肽类似物及其用途
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申请号： US13594313申请日： 2012-08-24
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公开(公告)号： US08853160B2公开(公告)日： 2014-10-07
- 发明人: Nigel H. Greig , Josephine M. Egan , Maire Doyle , Harold W. Holloway , Tracy Perry
- 申请人： Nigel H. Greig , Josephine M. Egan , Maire Doyle , Harold W. Holloway , Tracy Perry
- 申请人地址： US MD Rockville
- 专利权人： The United States of America, as represented by the Secretary, Department of Health & Human Services
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health & Human Services
- 当前专利权人地址： US MD Rockville
- 代理机构： Edwards Wildman Palmer LLP
- 代理商 Peter F. Corless
- 主分类号： A61K38/26
- IPC分类号： A61K38/26 ; A61P3/10 ; A61P7/12 ; C07K14/605 ; C07K14/575 ; A61K38/00 ; A61K38/22
摘要：
The invention relates to novel polypeptide analogs of GLP-1 and exendin-4. The polypeptide, in a preferred embodiment, is insulinotropic and long-acting. Preferably, the polypeptide's insulinotropic effect is comparable to or exceeds the effect of an equimolar amount of GLP-1 or exendin-4. The invention also relates to a method of treating a subject with diabetes, comprising administering to the subject the polypeptide of the invention in an amount that has an insulinotropic effect. The invention also relates to methods of using GLP-1, exendin-4, and polypeptide analogs thereof for neuroprotective and neurotrophic effects.
公开/授权文献
- US20120329715A1 GLP-1, EXENDIN-4, PEPTIDE ANALOGS AND USES THEREOF 公开/授权日：2012-12-27
信息查询
IPC分类:
