A safety shut-off system and method for eliminating power to a load in the event of smoke detection. The system may comprise a device located at the appliance for detecting a signal from a smoke detector, and cutting power to the appliance only when the appliance is in use. The device may be synchronized with any standard smoke alarm signal to reduce the number of false positive shut-offs. The system may also comprise a smoke alarm hard-wired to a circuit breaker, for shutting off power to all appliances on a particular breaker upon receipt of a signal from the smoke alarm, and only when the appliances on the breaker are in use. The system may also have the ability to shut off one breaker, multiple breakers, or all breakers at different time increments to actively prevent and reduce the damages caused by fires.