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US08834893B2 Nucleic acid derived from hepatitis C virus and expression vector, transformed cell, and hepatitis C virus particles each prepared by using the same 有权
衍生自丙型肝炎病毒的核酸和表达载体，转化细胞和丙型肝炎病毒颗粒各自通过使用它们制备

Nucleic acid derived from hepatitis C virus and expression vector, transformed cell, and hepatitis C virus particles each prepared by using the same
Abstract:
The present invention provides a nucleic acid comprises a 5′ untranslated region, an NS3 protein coding region, an NS4A protein coding region, an NS4B protein coding region, an NS5A protein coding region, an NS5B protein coding region, and a 3′ untranslated region of a hepatitis C virus genome, wherein the nucleic acid has nucleotide substitutions causing one or more amino acid substitutions selected from the group consisting of M(1205)K, F(1548)L, C(1615)W, T(1652)N, A(2196)T, A(2218)S, H(2223)Q, Q(2281)R, K(2520)N, and G(2374)S, as defined using the amino acid sequence shown in SEQ ID NO: 6 in the Sequence Listing as a reference sequence, in the NS3 protein coding region, the NS5A protein coding region, or the NS5B protein coding region.
Abstract(Chinese):

本发明提供了包含5'非翻译区，NS3蛋白编码区，NS4A蛋白编码区，NS4B蛋白编码区，NS5A蛋白编码区，NS5B蛋白编码区和3'非翻译区的核酸 的丙型肝炎病毒基因组，其中所述核酸具有引起一个或多个氨基酸取代的核苷酸取代，所述氨基酸取代选自M（1205）K，F（1548）L，C（1615）W，T（1652）N ，A（2196）T，A（2218）S，H（2223）Q，Q（2281）R，K（2520）N和G（2374）S，如使用SEQ ID NO ：序列表中的6作为参考序列，在NS3蛋白编码区，NS5A蛋白编码区或NS5B蛋白编码区。

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