发明授权
- 专利标题： Molecular tweezers for the treatment of amyloid-related diseases
- 专利标题（中）： 用于治疗淀粉样蛋白相关疾病的分子镊子
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申请号： US13203962申请日： 2010-03-05
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公开(公告)号： US08791092B2公开(公告)日： 2014-07-29
- 发明人: Gal Bitan , Akila Shanmugam , Aleksey Lomakin , Thomas Schrader , Frank Gerrit Klarner , Peter Talbiersky , Jolanta Polkowska , Frank Bastkowski , Sharmistha Sinha , Sally Frautschy
- 申请人： Gal Bitan , Akila Shanmugam , Aleksey Lomakin , Thomas Schrader , Frank Gerrit Klarner , Peter Talbiersky , Jolanta Polkowska , Frank Bastkowski , Sharmistha Sinha , Sally Frautschy
- 申请人地址： US CA Oakland US DC Washington US MA Cambridge DE Essen
- 专利权人： The Regents of the University of California,The United States of America as represented by the Department of Veterans Affairs,Massachusetts Institute of Technology,Universitat Duisburg-Essen
- 当前专利权人： The Regents of the University of California,The United States of America as represented by the Department of Veterans Affairs,Massachusetts Institute of Technology,Universitat Duisburg-Essen
- 当前专利权人地址： US CA Oakland US DC Washington US MA Cambridge DE Essen
- 代理机构： Weaver Austin Villeneuve & Sampson LLP
- 代理商 Tom Hunter
- 国际申请： PCT/US2010/026419 WO 20100305
- 国际公布： WO2010/102248 WO 20100910
- 主分类号： A61K31/6615
- IPC分类号： A61K31/6615 ; A61K31/663 ; C07K14/47 ; C07F9/40 ; C07F9/12
摘要：
This invention provides novel compositions to inhibit the aggregation of amyloid proteins. In various embodiments the compositions comprise a molecular tweezers that binds lysine and/or arginine and thereby inhibits the aggregation of amyloidogenic proteins.
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