发明授权
- 专利标题： Tetrazolyl macrocyclic hepatitis C serine protease inhibitors
- 专利标题（中）： 四唑基大环丙型肝炎丝氨酸蛋白酶抑制剂
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申请号： US12016659申请日： 2008-01-18
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公开(公告)号： US08785377B2公开(公告)日： 2014-07-22
- 发明人: Ying Sun , Dong Liu , Yat Sun Or , Zhe Wang
- 申请人： Ying Sun , Dong Liu , Yat Sun Or , Zhe Wang
- 申请人地址： US MA Watertown
- 专利权人： Enanta Pharmaceuticals, Inc.
- 当前专利权人： Enanta Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Watertown
- 代理机构： Elmore Patent Law Group, P.C.
- 代理商 Edgar W. Harlan; Carolyn S. Elmore, Esq.
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A01N37/18 ; A61K31/41 ; A61K31/13 ; C07K5/083 ; C07D487/04 ; A61K38/21 ; A61K31/7056 ; A61K45/06
摘要：
The present invention relates to compounds of Formula I, II, III or IV, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.
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