发明授权
- 专利标题: Crystal of fused pyridine compound salt
- 专利标题(中): 稠合吡啶化合物的晶体
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申请号: US13806909申请日: 2011-06-22
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公开(公告)号: US08779140B2公开(公告)日: 2014-07-15
- 发明人: Takashi Kikuchi , Katsuhiko Gato , Koichiro Mukoyoshi , Tsuyoshi Kitamura , Takeshi Kawakami , Hironobu Yasuda
- 申请人: Takashi Kikuchi , Katsuhiko Gato , Koichiro Mukoyoshi , Tsuyoshi Kitamura , Takeshi Kawakami , Hironobu Yasuda
- 申请人地址: JP Tokyo
- 专利权人: Astellas Pharma Inc.
- 当前专利权人: Astellas Pharma Inc.
- 当前专利权人地址: JP Tokyo
- 代理机构: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- 优先权: JP2010-143226 20100623
- 国际申请: PCT/JP2011/064291 WO 20110622
- 国际公布: WO2011/162300 WO 20111229
- 主分类号: C07D471/04
- IPC分类号: C07D471/04
摘要:
[Problem]A salt or crystal of a compound which is highly stable in a solid state and useful as a bulk material for the preparation of a pharmaceutical product is provided.[Means for Solution]4-{[(1R,2s,3S,5s,7s)-5-Hydroxy-2-adamantyl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide succinate, 4-{[(1R,2s,3S,5s,7s)-5-hydroxy-2-adamantyl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrobromide, and 4-{[(1R,2s,3S,5s,7s)-5-hydroxy-2-adamantyl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide hydrochloride and crystals thereof are useful as a bulk material for the preparation of a solid preparation, in particular, a solid dispersion preparation. Furthermore, the crystal of the hydrobromide has excellent stability in a solid state and is useful as a bulk material for the preparation of a pharmaceutical product.
公开/授权文献
- US20130102628A1 CRYSTAL OF FUSED PYRIDINE COMPOUND SALT 公开/授权日:2013-04-25
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