Invention Grant
US08772459B2 J591 minibodies and Cys-diabodies for targeting human prostate specific membrane antigen (PSMA) and methods for their use
有权
用于靶向人前列腺特异性膜抗原（PSMA）的J591微型抗体和Cys-双抗体及其使用方法
- Patent Title: J591 minibodies and Cys-diabodies for targeting human prostate specific membrane antigen (PSMA) and methods for their use
- Patent Title (中): 用于靶向人前列腺特异性膜抗原（PSMA）的J591微型抗体和Cys-双抗体及其使用方法
-
Application No.: US12959340Application Date: 2010-12-02
-
Publication No.: US08772459B2Publication Date: 2014-07-08
- Inventor: David Ho , Tove Olafsen , Arye Lipman
- Applicant: David Ho , Tove Olafsen , Arye Lipman
- Applicant Address: US CA Inglewood
- Assignee: ImaginAb, Inc.
- Current Assignee: ImaginAb, Inc.
- Current Assignee Address: US CA Inglewood
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Main IPC: C07K16/30
- IPC: C07K16/30
Abstract:
In one embodiment, a minibody monomer that binds PSMA is provided. The minibody monomer is encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA, an artificial hinge sequence, and a human IgG CH3 sequence. In another embodiment, a CysDB monomer that binds PSMA is provided. The CysDB monomer may be encoded by a nucleotide sequence comprising, from N-terminus to C-terminus, an scFv sequence that can bind PSMA and a cysteine tail. In other embodiments, methods for diagnosing or treating a cancer associated with PSMA expression in a subject are provided.
Public/Granted literature
Information query
