发明授权
- 专利标题： Antibodies against HER2 truncated variant CTF-611
- 专利标题（中）： 针对HER2截短型CTF-611的抗体
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申请号： US12961004申请日： 2010-12-06
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公开(公告)号： US08741586B2公开(公告)日： 2014-06-03
- 发明人: Joaquin Arribas Lopez , Kim Pedersen , Pier-Davide Angellini , Josep Lluis Parra Palau , Jose Baselga Torres
- 申请人： Joaquin Arribas Lopez , Kim Pedersen , Pier-Davide Angellini , Josep Lluis Parra Palau , Jose Baselga Torres
- 申请人地址： ES Barcelona ES Barcelona
- 专利权人： Fundacio Privada Institucio Catalana de Recerca i Estudis Avancats,Fundacio Privada Institut d'Investigacio Oncologica de vall d'Hebron
- 当前专利权人： Fundacio Privada Institucio Catalana de Recerca i Estudis Avancats,Fundacio Privada Institut d'Investigacio Oncologica de vall d'Hebron
- 当前专利权人地址： ES Barcelona ES Barcelona
- 代理机构： McAndrews, Held & Malloy
- 优先权： EP09380183 20091207
- 主分类号： C12P21/08
- IPC分类号： C12P21/08 ; C07K16/30 ; C07K16/28 ; G01N33/574 ; G01N33/573 ; G01N33/567 ; G01N33/50
摘要：
The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor.The invention provides antibodies or fragments thereof that recognise an epitope of the HER2 receptor truncated form CTF-611, said epitope being defined by a sequence included in SEQ ID NO: 2, and that are capable of discriminating between CTF-611 and CTF-616 (represented by SEQ ID NO:7), preferably additionally capable of discriminating between CTF-611 and CTF-613 (represented by SEQ ID NO:6).The invention also provides a method of cancer diagnosis using the disclosed antibodies, which comprises the detection of the presence of the HER2 receptor truncated form consisting of the amino acid sequence SEQ ID NO: 1 in a patient sample.
公开/授权文献
- US20110135653A1 Antibodies Against HER2 Truncated Variant CTF-611 公开/授权日：2011-06-09
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