A method and an apparatus for pre-scheduling in a closed-loop multiple user multiple input multiple output (MU-MIMO) antenna system. A base station receives channel information representing a downlink channel condition of each mobile station from mobile stations in a cell, and determines a candidate user group for each of frequency bands included in an entire frequency band, based on the channel information, the candidate user group including mobile stations to which resources can be simultaneously allocated. The base station also instructs a mobile station included in each candidate user group to transmit a sounding signal through a corresponding frequency band. If the sounding signal is received through the corresponding frequency band, the base station performs a scheduling with regard to the mobile station included in each candidate user group.