An adaptive mouse is disclosed. In the adaptive mouse, a cover layer made of a moldable material covers a mouse body, and a plurality of sensors is disposed between the mouse body and the cover layer. The sensors are used to sense a hand shape of a user when the user holds the cover layer. The sensors under the left and right finger predicting areas are defined as a left button and a right buttons to allow the user to operate the mouse normally. Then, the displacement signal of the mouse is adjusted. The adaptive mouse may increase comfortableness and relieve fatigue, and it also may be adapted to any holding states without orientation limitation.