An apparatus for sanitizing oral appliances is provided. The apparatus includes a housing movable between open and closed positions, at least one ultraviolet light source for emitting one or more sanitization means within the sanitizing chamber, and at least one power source for powering the ultraviolet light source. In the open position the housing allows insertion of the appliance, and in the closed position the housing defines a sanitizing chamber. The apparatus may include an appliance suspension system. The apparatus may include a reflective interior surface provided on at least a portion of the sanitizing chamber. The ultraviolet light source may be adapted to generate ozone within the sanitizing chamber. The apparatus may include control circuitry connecting the ultraviolet light source to the power source for the purpose of activating and deactivating the ultraviolet light source.