发明授权
- 专利标题: P2X4 receptor antagonist
- 专利标题(中): P2X4受体拮抗剂
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申请号: US13811909申请日: 2011-07-27
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公开(公告)号: US08680110B2公开(公告)日: 2014-03-25
- 发明人: Masatoshi Ushioda , Shogo Sakuma , Toshiyasu Imai , Kazuhide Inoue
- 申请人: Masatoshi Ushioda , Shogo Sakuma , Toshiyasu Imai , Kazuhide Inoue
- 申请人地址: JP Tokyo
- 专利权人: Nippon Chemiphar Co., Ltd.
- 当前专利权人: Nippon Chemiphar Co., Ltd.
- 当前专利权人地址: JP Tokyo
- 代理机构: Nixon Peabody LLP
- 代理商 Jeffrey L. Costellia
- 优先权: JP2010-174240 20100803
- 国际申请: PCT/JP2011/067028 WO 20110727
- 国际公布: WO2012/017876 WO 20120209
- 主分类号: A61K31/517
- IPC分类号: A61K31/517 ; A61K31/519 ; C07D239/70
摘要:
A compound having the following formula (II) or a pharmacologically acceptable salt thereof is used as a P2X4 receptor antagonist: wherein each of R11 and R12 is hydrogen, C1-8 alkyl or the like; R13 is hydrogen, C1-8 alkyl or the like; R14 is C1-8 alkoxy, hydroxyl, cyano, a heterocyclic group optionally having a substituent or the like; and the condensed ring consisting of W1 and the neighboring benzene ring is naphthalene ring or the like.
公开/授权文献
- US20130184459A1 P2X4 RECEPTOR ANTAGONIST 公开/授权日:2013-07-18
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