Invention Grant
- Patent Title: Gamma secretase modulators
- Patent Title (中): 伽玛分泌酶调节剂
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Application No.: US13128493Application Date: 2009-11-12
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Publication No.: US08673900B2Publication Date: 2014-03-18
- Inventor: Zhaoning Zhu , William J. Greenlee , Xianhai Huang , Jun Qin , Xiaoxiang Liu , Hongmei Li , Wei Zhou , Anandan Palani , Xiaohong Zhu , Monica L. Vicarel , Mihirbaran Mandal , Zhong-Yue Sun , Chad E. Bennett , Troy Michael McCracken , Gioconda V. Gallo
- Applicant: Zhaoning Zhu , William J. Greenlee , Xianhai Huang , Jun Qin , Xiaoxiang Liu , Hongmei Li , Wei Zhou , Anandan Palani , Xiaohong Zhu , Monica L. Vicarel , Mihirbaran Mandal , Zhong-Yue Sun , Chad E. Bennett , Troy Michael McCracken , Gioconda V. Gallo
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Susan L. Hess; Raynard Yuro; John C. Todaro
- International Application: PCT/US2009/064190 WO 20091112
- International Announcement: WO2010/056849 WO 20100520
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D498/04 ; A61K31/5395
Abstract:
In many embodiments, the present invention provides novel heterocyclic compounds which are modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more disease associated with the central nervous system using such compounds or pharmaceutical compositions.
Public/Granted literature
- US20110294756A1 GAMMA SECRETASE MODULATORS Public/Granted day:2011-12-01
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