A system and method for dynamic profile management in a cable modem termination system (CMTS) is provided. A CMTS receiver is in communications with a plurality of cable modems, and a dynamic profile management module is in communication with the CMTS receiver. The dynamic profile management module establishes a communications profile for an upstream channel used by the CMTS receiver and at least one of the plurality of cable modems (the communications profile including a plurality of parameters associated with the upstream channel), continuously monitors performance metrics associated with communications across the upstream channel, and automatically adjusts the plurality of parameters of the communications profile in response to the monitored performance metrics.