发明授权
- 专利标题: Quinoline-carboxamide derivatives as P2Y12 antagonists
- 专利标题(中): 喹啉 - 甲酰胺衍生物作为P2Y12拮抗剂
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申请号: US12573551申请日: 2009-10-05
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公开(公告)号: US08669266B2公开(公告)日: 2014-03-11
- 发明人: Marc Nazare , Gernot Zech , Melitta Just , Tilo Weiss , Gerhard Hessler , Joerg Czech
- 申请人: Marc Nazare , Gernot Zech , Melitta Just , Tilo Weiss , Gerhard Hessler , Joerg Czech
- 申请人地址: FR Paris
- 专利权人: Sanofi
- 当前专利权人: Sanofi
- 当前专利权人地址: FR Paris
- 代理机构: Scully, Scott, Murphy & Presser, P.C.
- 优先权: EP07008209 20070423
- 主分类号: A01N43/42
- IPC分类号: A01N43/42 ; A61K31/44
摘要:
The present invention relates to compounds of the formula I, in which R1; R2; R3; R4; R5; R6; Z; A; B; E; X; Q; J; V; G and M have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong anti-aggregating effect on platelets and thus an anti-thrombotic effect and are suitable e.g. for the therapy and prophylaxis of cardio-vascular disorders like thromboembolic diseases or restenoses. They are reversible antagonists of the platelet ADP receptor P2Y12, and can in general be applied in conditions in which an undesired activation of the platelet ADP receptor P2Y12 is present or for the cure or prevention of which an inhibition of the platelet ADP receptor P2Y12 is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.
公开/授权文献
- US20100135999A1 QUINOLINE-CARBOXAMIDE DERIVATIVES AS P2Y12 ANTAGONISTS 公开/授权日:2010-06-03
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