The present invention provides a method and apparatus for multi-user multiplexing. The method includes: a transmission apparatus performing layer mapping on data steams to be transmitted of an open-loop user and a close-loop user respectively; the transmission apparatus performing pre-coding processing on a layer data matrix of the open-loop user and the close-loop user obtained by the layer mapping; and the transmission apparatus mapping the layer data matrix after the pre-coding processing to a plurality of transmission antennas to be sent. The method of the present invention can improve frequency spectrum utilization ratio in the case of the a cell being full load or other possible scenarios, and its performance is better than the multiplexing of two close-loop users who are completely not suitable for pairing. Therefore, the method of the present invention is an optimal scheme adopted in some specified scenarios.