发明授权
US08637681B2 Pyrrolyl substituted dihydroindol-2-one derivatives, preparation methods and uses thereof
失效
吡咯基取代的二氢吲哚-2-酮衍生物,其制备方法和用途
- 专利标题: Pyrrolyl substituted dihydroindol-2-one derivatives, preparation methods and uses thereof
- 专利标题(中): 吡咯基取代的二氢吲哚-2-酮衍生物,其制备方法和用途
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申请号: US13702956申请日: 2011-03-31
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公开(公告)号: US08637681B2公开(公告)日: 2014-01-28
- 发明人: Jingyi Wang , Chuanwen Fan , Long Zhang , Boyan Xu , Shousheng Yan , Zongru Guo , Minghui Zhang , Dong Lin , Zhantao Zhang , Haojie Zhou
- 申请人: Jingyi Wang , Chuanwen Fan , Long Zhang , Boyan Xu , Shousheng Yan , Zongru Guo , Minghui Zhang , Dong Lin , Zhantao Zhang , Haojie Zhou
- 申请人地址: CN Jinan, Shandong
- 专利权人: Qilu Pharmaceutical Co., Ltd.
- 当前专利权人: Qilu Pharmaceutical Co., Ltd.
- 当前专利权人地址: CN Jinan, Shandong
- 代理机构: Seed IP Law Group PLLC
- 优先权: CN201010194609 20100608
- 国际申请: PCT/CN2011/000561 WO 20110331
- 国际公布: WO2011/153814 WO 20111215
- 主分类号: C07D401/14
- IPC分类号: C07D401/14 ; C07D403/14 ; C07D413/14 ; C07D411/06 ; A61K31/403 ; A61K31/497 ; A61K31/535
摘要:
Provided are pyrrolyl substituted dihydroindol-2-one derivatives represented by formula (I), pharmaceutically acceptable salts or solvates of said derivatives, or solvates of said salts, which are effective tyrosine kinase inhibitors. Also provided are the preparation methods of the above compounds, pharmaceutical compositions containing these compounds, and the use of these compounds in manufacturing drugs useful for the treatment or adjunctive treatment of tumors medicated by tyrosine kinases or proliferation or migration of tumor cells driven by tyrosine kinases in mammals (including human).
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