发明授权
US08637453B2 Pyruvamide compounds as inhibitors of dust mite group 1 peptidase allergen and their use
有权
丙酮酰胺化合物作为尘螨组1肽酶过敏原的抑制剂及其用途
- 专利标题： Pyruvamide compounds as inhibitors of dust mite group 1 peptidase allergen and their use
- 专利标题（中）： 丙酮酰胺化合物作为尘螨组1肽酶过敏原的抑制剂及其用途
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申请号： US13852138申请日： 2013-03-28
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公开(公告)号： US08637453B2公开(公告)日： 2014-01-28
- 发明人: Clive Robinson , Jihui Zhang , David Ronald Garrod , Trevor Robert Perrior , Gary Karl Newton , Kerry Jenkins , Rebekah Elisabeth Key , Meriel Ruth Major , Mark Richard Stewart
- 申请人： St George's Hospital Medical School , The University of Manchester
- 申请人地址： GB London GB Manchester
- 专利权人： St George's Hospital Medical School,The University of Manchester
- 当前专利权人： St George's Hospital Medical School,The University of Manchester
- 当前专利权人地址： GB London GB Manchester
- 代理机构： Swanson & Bratschun, L.L.C.
- 优先权： GB1001070.0 20100122
- 主分类号： A61K31/16
- IPC分类号： A61K31/16
摘要：
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain pyruvamide compounds of the following formula (for convenience, collectively referred to herein as “PVA compounds”), which, inter alia, inhibit a dust mite Group 1 peptidase allergen (e.g., Der p 1, Der f 1, Eur m 1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit a dust mite Group 1 peptidase allergen, and in the treatment of diseases and disorders that are mediated by a dust mite Group 1 peptidase allergen; that are ameliorated by the inhibition of a dust mite Group 1 peptidase allergen; asthma; rhinitis; allergic conjunctivitis; atopic dermatitis; an allergic condition which is triggered by dust mites; an allergic condition which is triggered by a dust mite Group 1 peptidase allergen; and canine atopy.
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