发明授权
- 专利标题： Postprandial hyperglycemia marker, method of measuring the same, and usage thereof
- 专利标题（中）： 餐后高血糖标记，测量方法及其用途
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申请号： US12376914申请日： 2007-08-10
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公开(公告)号： US08637275B2公开(公告)日： 2014-01-28
- 发明人: Satoshi Yonehara , Toshihiro Imai
- 申请人： Satoshi Yonehara , Toshihiro Imai
- 申请人地址： JP Kyoto
- 专利权人： ARKRAY, Inc.
- 当前专利权人： ARKRAY, Inc.
- 当前专利权人地址： JP Kyoto
- 代理机构： Morgan, Lewis & Bockius LLP
- 优先权： JP2006-220678 20060811
- 国际申请： PCT/JP2007/065768 WO 20070810
- 国际公布： WO2008/018596 WO 20080214
- 主分类号： C12P21/04
- IPC分类号： C12P21/04
摘要：
A new method of diagnosing postprandial hyperglycemia by indirectly measuring a blood glucose level is provided. Postprandial hyperglycemia is detected by measuring a glycation degree of lysine in hemoglobin, in which a side chain amino group of lysine is glycated (GHbLys %). Measurement of GHbLys % can be performed by cleaving hemoglobin by protease, treating a glycated part of a lysine residue in the obtained cleavage product of hemoglobin with fructosyl amino acid oxidase, and measuring a redox reaction between the glycated part and fructosyl amino acid oxidase.
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