发明授权
US08636979B2 TLR 4 and 9 receptors agonists for preventing septic complications of post-traumatic immunodepression in patients hospitalized for severe traumatic injuries
有权
TLR4和9受体激动剂，用于预防重度创伤性损伤住院患者的创伤后免疫抑制的败血症并发症
- 专利标题： TLR 4 and 9 receptors agonists for preventing septic complications of post-traumatic immunodepression in patients hospitalized for severe traumatic injuries
- 专利标题（中）： TLR4和9受体激动剂，用于预防重度创伤性损伤住院患者的创伤后免疫抑制的败血症并发症
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申请号： US13519531申请日： 2010-12-17
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公开(公告)号： US08636979B2公开(公告)日： 2014-01-28
- 发明人: Karim Asehnoune
- 申请人： Karim Asehnoune
- 申请人地址： FR Nantes FR Nantes
- 专利权人： Chu Nantes,Universite de Nantes
- 当前专利权人： Chu Nantes,Universite de Nantes
- 当前专利权人地址： FR Nantes FR Nantes
- 代理机构： Foley & Lardner LLP
- 优先权： FR0906372 20091228
- 国际申请： PCT/EP2010/070111 WO 20101217
- 国际公布： WO2011/080126 WO 20110707
- 主分类号： A61K49/00
- IPC分类号： A61K49/00 ; A61K39/02 ; A61K45/00
摘要：
The present invention concerns a pharmaceutical composition comprising at least one agonist of at least one Toll Like receptor (TLR) chosen from TLR 4 and 9, for use in the prophylactic treatment of septic complications of post-traumatic systemic immunodepression in a patient who has suffered one or more severe traumatic injuries and is hospitalized in particular in an intensive care unit. Preferably, said TLR 4 agonist is monophosphoryl lipid A (MPLA) or deacylated 3-O-monophosphoryl lipid A (3D-MPLA) and said TLR 9 agonist is a CpG oligodeoxynucleotide (CpG ODN).
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