An apparatus and method for transmitting and receiving a signal and a subcarrier allocation structure therefor in a multi-user multi-antenna communication system are provided, in which a transmitter calculates receive filters for each of a plurality of receivers or for a plurality of antennas in a receiver, determines the index of a vector having a correlation with the calculated receive filters in a preset codebook vector to be a receive filter index, and transmits the receive filter index to the receiver.