发明授权
- 专利标题： Forms of CDDO methyl ester
- 专利标题（中）： 形式的CDDO甲酯
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申请号： US13537583申请日： 2012-06-29
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公开(公告)号： US08633243B2公开(公告)日： 2014-01-21
- 发明人: John Walling , Stephan D. Parent , David T. Jonaitis , Robert M. Kral, Jr.
- 申请人： John Walling , Stephan D. Parent , David T. Jonaitis , Robert M. Kral, Jr.
- 申请人地址： US TX Irving
- 专利权人： Reata Pharmaceuticals, Inc.
- 当前专利权人： Reata Pharmaceuticals, Inc.
- 当前专利权人地址： US TX Irving
- 代理机构： Foley & Lardner LLP
- 主分类号： A61K31/21
- IPC分类号： A61K31/21
摘要：
A triterpenoid compound, methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous crystalline form that can prepared, for example, from a saturated methanol solution. The glassy form displays an enhanced bioavailability over the non-hydrous crystalline form. Each form of CDDO methyl ester is a superior candidate for use, typically in solid dosage form, for treating a variety of disease states, generally associated with inflammation.
公开/授权文献
- US20120330050A1 NOVEL FORMS OF CDDO METHYL ESTER 公开/授权日：2012-12-27
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